Activators

There is provided a cyanoacrylate composition comprising: a cyanoacrylate; and a 2-substituted benzothiazole or a derivative thereof wherein the 2-substituent is an alkyl, an alkene, an alkylbenzyl, an alkylamino, an alkoxy, an alkylhydroxy, an ether, a sulfenamide, a thioalkyl or a thioalkoxy group, with the proviso that an amide portion of the sulfenamide does not have a tert butylamino or a morpholine group.

A composition comprising a polymerizable adhesive monomer is applied over a biologically active initiator or accelerator for polymerization of the monomer. The biologically active initiator or accelerator is a medicament that provides a desired medical or therapeutic activity as well as enhancing polymerization of the adhesive.

This invention concerns polymerization accelerators or surface activators for increasing the rate of cure of cyanoacrylate adhesive compositions. The active ingredients of the activators are organic compounds containing a N-C=S or a N=C-S group.

A method is disclosed for initiating the polymerization of small amounts of relatively sensitive liquid monomer compositions, comprising esters of cyanoacrylic acid, by means of a polymerization catalyzing particle adapted to the added to the monomer composition and then separated from the same prior to the gelation of the monomer. The catalyzing particle may be in the form of a discrete particle such as beads, chips, or the like, or in the form of a rod sufficiently long so that the same can be used to simultaneously stir and activate the monomer.

An adhesive composition comprising an adhesive base and accelerator portion, the adhesive base comprising (a) a polymerizable monomer selected from the group consisting of unsubstituted alpha-cyanoacrylates and substituted alpha-cyanoacrylates; and (b) an effective amount of stabilizer; and the accelerator portion comprising a weakly acidic or weakly basic ionic accelerator compound comprising a cation M and an anion A, the pKa relating to cation M in the equilibrium defined by M(H2O) + = MOH + H+ being at least about 10, the pKa relating to anion A in the equilibrium defined by HA= A- + H+

A sterilized cyanoacrylate adhesive composition including a cyanoacrylate composition and a cure speed enhancer, wherein said sterilized cyanoacrylate adhesive composition does not cure upon sterilization, and wherein the composition when cured to form a film on a patient's tissue has water vapor transmission rate from about 950 to about 3000 g/m2/day.