PVP Based

Disclosed are methods for draping a surgical incision site prior to surgery. Specifically, the methods of this invention involve the in situ formation of a cyanoacrylate polymeric drape over the skin surface at the surgical incision site. An incision is then made through this surface and the surgery is then conducted through the incision

Bloodstream infections related to use of catheters, particularly central-line catheters, are an important cause of patient morbidity, mortality, and increased health care costs. This study evaluated the efficacy of skin disinfection with chlorhexidine gluconate compared with povidone-iodine solution in preventing catheter-related bloodstream infection.

Single wall carbon nanotubes (SWCNTs) are coated with polyvinylpyrrolidone-iodine (povi- done-iodine or PVPI) in water. This solution of SWCNT and PVPI is deposited as a composite film, composed of individual and bundled SWCNTs with a PVPI coating. This material acts as a conductive nanotextured bandage with high flexibility and self contained slow-release antiseptic iodine. Antibacterial properties were tested on Escherichia coli, showing high effi- cacy over 48 h. Four-probe resistance tests showed a sheet resistance of approximately 10 kX/h.

Disclosed are mixed alkyl cyanoacrylate compositions which are specifically formulated for topical application onto intact or broken human skin, preferably without the addition of a plasticizing agent to the composition.

The incidence of postoperative wound infection following the use of an iodophor-incorporated adhesive wound drape with a preliminary one-minute alcohol cleanse was observed in 649 total arthroplasties. The patients were followed for a minimum of one year to detect signs of infection. An infection rate of 0.46% was comparable to the incidence previously observed for conventional methods using an iodine spray as a skin preparation.

A cyanoacrylate adhesive is applied onto surface skin areas prone to ulceration or irritation so as to inhibit irritation of the surface skin due to contact with an artificial device such as prosthetic devices, bandages, casts, etc.

A cyanoacrylate adhesive is applied onto skin area prone to exposure to discharge by patients suffering from incontinence so as to shield the skin from direct contact with the discharge. The adhesive can also be applied over medicament that has been applied onto skin surface and onto skin along the periphery of a stoma.