2008

An article, such as a tissue bonding article, includes a flexible material, a polymerization initiator or rate modifier disposed in or on the flexible material, and a polymerizable adhesive composition permeated throughout at least a portion of the flexible material, where the polymerization initiator or rate modifier is a polymerization initiator or rate modifier for the polymerizable adhesive composition.

N.A.

A general methodology was proposed to prepare highly functionalized poly(alkyl cyanoacrylate) nanoparticles by means of Huisgen 1,3-dipolar cyclo-addition, the so-called click chemistry.

An adhesive composite composition is provided including one or more polymerizable monomers and one or more metal stearates. The one or more polymerizable monomers may be a cyanoacrylate monomer. The adhesive composite composition may further comprise a plasticizer, an initiator, a rate modifier, a stabilizer, a colorant, a heat dissipating agent, or other additives. Methods for the application of the adhesive composite compositions to living tissue are also provided.

The present invention relates to the use, for treating the hair, of a composition containing, in a cosmetically acceptable medium, at least one monomer capable of polymerizing by anionic polymerization in the presence of a nucleophilc agent.

By using fluorescent polysorbate 80 coated poly(n-butylcyanoacrylate) (PBCA) nanoparticles in an in vivo study, direct evidence was found for the presence of nanoparticles entering the brain and retina of rats. The nanoparticles, prepared with a miniemulsion process, were labeled in situ with a fluorescent dye and coated with polysorbate 80. After preparation the particle size, ζ potential, and the molecular weight distribution were determined. BMEC cells were used as an in vitro model for the BBB.

Purpose: To analyze the antibacterial effects in vitro of ethyl- cyanoacrylate (EC) tissue adhesive in different application volumes. Methods: Volumes of 4, 6, 8, 10, 12, 14, 25, and 35 μl of EC were applied onto the sur- face of monolayer cultures of Staphylococcus aureus (ATCC25924), Streptococcus pneumoniae (ATCC49619), Escherichia coli (ATCC25922), Pseudomonas aeruginosa (ATCC27853), and Klebsiella pneumoniae (ATCC13883). The diameter of each EC drop was measured, and the area of the circle of EC (formed after its appli- cation onto the monolayer culture) was calculated.

This report analyzes the US market for Medical Adhesives and Sealants in US$ Million. The major product segments analyzed are Dental Adhesives & Sealants (Denture & Orthodontic Bonding Agents, Pit & Fissure Sealants and Luting Cements, Restorative Adhesives, Tray Adhesives, and Dental Surgical Tissue Bonding Agents), and Medical Adhesives & Sealants (Surgical/Internal Medical Adhesives & Sealants, and External Medical Adhesives & Sealants). Annual forecasts are provided for the period of 2000 through 2015.

Over the past century, synthetic adhesives have largely displaced their natural counterparts in medical applications. However, rising concerns over the environmental and toxicological effects of the solvents, monomers, and additives used in synthetic adhesives have recently led the scientific community to seek natural substitutes. Marine mussel adhesive protein is a formaldehyde-free natural adhesive that demonstrates excellent adhesion to several classes of materials, including glasses, metals, metal oxides, and polymers.

This invention addresses absorbable cyanoacrylate-based tissue adhesive compositions based primarily on an alkoxy cyanoacrylate combined with one or more alkyl cyanoacrylate(s), a stabilizer against premature anionic polymerization, and/or an absorbable polymeric modifier with improved, and preferably, functional properties for use, primarily, for internal wound repair applications.