Patent

Novel methods and devices which provide enhanced mixing and application of two liquid components to form a biomaterial with minimized aerosols is achieved using air flow rates below about 1.25 liters/minute in combination with a ratio of air flow to total liquid flow of from about 150:1 up to about 1500:1. Preferably the air flow is below about 1 liter/minute and the ratio of air flow to total liquid flow is from about 200:1 to about 1200:1. The parameters are ideally suited for the spray application of components which form a surgical sealant, e.g., a fibrin sealant.

The invention relates to methods of using compositions for forming microbial sealant drapes. In particular, the invention relates to the use of compositions of combinations of cyanoacrylates for the in situ formation of drapes that can be used in surgery to protect patients from surgical site infections.

A monomer composition comprising at least one polymerizable alkyl ester α-cyanoacrylate monomer. Specifically, the α-cyanoacrylate monomer is an alkyl ester α-cyanoacrylate monomer of the general formula having a spacer R1:

The present invention is directed to bioabsorbable adhesive/hemostatic formulations of a 2-alkoxyalkylcyanoacrylate and liquid or solid polymeric modifiers and adjuvant. The present adhesive formulations are useful as tissue adhesive/sealants, hemostatic agents, and as a means for patching or anastomic coupling of damaged organs.

An adhesive composition for surgical use including an α-cyanoacrylate adhesive composition with a polymer characteristic for biodegrading and bioabsorbing the adhesive into the body of a living organism. It is preferred that the polymer is a co-polymer of DL-lactic acid and ϵ-caprolactone or a co-polymer of DL-lactic acid, ethylene glycol and ϵ-caprolactone, or a co-polymer of ethylene glycol and ϵ-caprolactone.

Tissue adhesive compostions are disclosed which comprise at least one 2-cyanoacrylate ester of the general formula (I) in admixture with from about 2 percent to about 25 percent of at least one oxalic acid polymer of the general formula (II).

A solid cyanoacrylate adhesive composition is disclosed which can be applied to a substrate in solid form and which polymerizes into an adhesive polymer upon liquefying. Preferably the solid cyanoacrylate composition liquefies at temperatures slightly above room temperature and polymerizes upon liquification. -caprolactones are used as a solidifying polymer with cyanoacrylate monomers and other additives to form the solid cyanoacrylate adhesive composition.

A biocompatible monomer composition contains (A) at least one monomer of the formula:

CHR=CXY

Bioabsorbable cyanoacrylate-based tissue adhesives containing bioabsorbable copolymers are disclosed. The copolymers are preferably derived from .epsilon.-caprolactone, lactide and glycolide monomers or from butyl 2-cyanoacrylate, glycolide, lactide, .epsilon.-caprolactone monomers. The adhesives are characterized by increased biodegradability, increased viscosity and increased flexibility. The adhesives are useful for wound and incision closure, and for medical devices, including implants.