Patent

This invention addresses absorbable cyanoacrylate-based tissue adhesive compositions based primarily on an alkoxy cyanoacrylate combined with one or more alkyl cyanoacrylate(s), a stabilizer against premature anionic polymerization, and/or an absorbable polymeric modifier with improved, and preferably, functional properties for use, primarily, for internal wound repair applications.

Disclosed are cyanoacrylate compositions comprising a compatible antimicrobial agent and, in particular, a compatible iodine containing antimicrobial agent. These compositions provide for in situ formation of an antimicrobial polymeric cyanoacrylate film of mammalian skin.

This invention relates to stabilized adhesives, to which silyl esters are added for stabilization.

This invention relates to an improved for preparing a dry powdered adduct of iodine and polymeric 1-vinyl-2-pyrrolidone (hereinafter called polyvinylpyrrolidone) whereby a stable composition is formed which is readily available and germicidally and bactericidally active form which is essentially non-toxic to warm-blooded animals.

This invention relates to the preparation of an adduct of iodine and polymeric 1-vinyl-2-pyrrolidone (hereinafter referred to as polyvinylpyrrolidone) whereby there is fomred a composition which is readily soluble in water to form a stable solution and which provides iodine in readily available germicidally and bactericidally active form which is essentially non-toxic to warm-blooded animals.

This invention relates to a process of stabilizing a dry powered adduct of iodine and polymeric 1-vinyl-2-pyrrolidone (hereinafter referred to as polyvinyl pyrrolidone) whereby a stable composition is obtained which when dissolved in water will not change its pH and maintain a constant available iodine content.

Disclosed are cyanoacrylate compositions comprising a compatible antimicrobial agent and, in particular, a compatible iodine containing antimicrobial agent. These compositions provide for in situ formation of an antimicrobial polymeric cyanoacrylate film on mammalian skin.

Alkyl cyanoacrylate compositions comprising at least one alkyl cyanoacrylate, a biocompatible plasticizer (preferably dioctyl phthalate), and SO.sub.2 as an artionic polymerization inhibitor are provided. These compositions are suitable for topical application to human skin.

An emulsion containing a substantially water resistant film-forming copolymer phase and iodine is claimed. The polymer-in-water emulsion forms a film that is a substantially fluid resistant, low tack, flexible film which adheres to skin and releases iodine to skin. The addition of iodate to emulsions having such a film-forming copolymer phase and iodine further enhances stability of the emulsion.

Disclosed are methods for draping a surgical incision site prior to surgery. Specifically, the methods of this invention involve the in situ formation of a cyanoacrylate polymeric drape over the skin surface at the surgical incision site. An incision is then made through this surface and the surgery is then conducted through the incision