Technical documentation

Disclosed are methods and formulations for the treatment or prevention of infections on mammalian tissues such as skin. Specifically, the methods of this invention involve the in situ formation of a polymeric cyanoacrylate film containing mixed antibiotics over mammalian tissue.

Flame retardant compositions are disclosed which comprise (a) at least one particulate material which expands on the application of heat and (b) at least one particulate nano-filler, together with at least one polymer and/or at least one curable monomer or oligomer. The compositions may also contain certain silicon-based materials. Flame-retardant compositions comprising polyorganosiloxanes containing one or more functional groups selected from amino, hydroxyl, methacrylic, acrylic and epoxy groups, are also disclosed.

Prior to the first clinical trials of doxorubicin-loaded nanoparticles, it was necessary to prepare this formulation in such a way as to meet the requirements generally associated with parenteral administration. This paper describes the conditions under which nanoparticles should be prepared and lyophilized in order to be sterile and free of bacterial endotoxins. These nanoparticles were also subjected to a resuspension test and their size and drug adsorption capacity were found practically unchanged.

A biocompatible monomer composition includes at least one monomer, which forms a medically acceptable polymer, and an effective amount of at least one heat dissipating agent sufficient to reduce exothermic polymerization temperature increase of the composition. The heat dissipating agent enhances patient comfort and prevents necrosis of living tissue normally encountered with such medical adhesives.