Polycyanoacrylate foam is made by mixing together a cyanoacrylate monomer, a liquid foaming agent and a polymerisation initiator. The mixture simultaneously polymerises and foams. The foaming agent is usually an organic compound with a boiling point not higher than 100 °C, miscible with the monomer but not a solvent for the polymer. The monomer may be any 2-cyanoacrylate ester compatible with the composition.
This invention relates to compositions which polymerize to form coatings and adhesives. More particularly, the invention relates to fluorin-containing cyanoacrylate monomers which polymerize rapidly upon contact with basic materials or materials supplying hydroxyl ions, e.g. moisture in the air, to form polymers which are suitable for biological application, i.e. to bond or coat living mammalian tissues.
wherein R is hydrogen, methyl or ethyl, R' is fluorine -CF3 or -(CF2)nH, and n is an integer from 1 to 3 have been found to be useful biological adhesives which when applied as monomers to aherends rapidly polymerize, e.g., in the presence of even small amounts of moisture, to form strong bonds. The monomers polymerize to films and can be used biologically as hemostatics and tissue adhesives.
A cyanoacrylate composition comprising (i) at least one lower cyanoacrylate monomer component selected from ethyl cyanoacrylate or methoxy ethylcyanoacrylate; (ii) at least one higher cyanoacrylate monomer component than in an amount greater than 12% by weight based on the total weight of the combination of the lower cyanoacrylate monomer and the higher cyanoacrylate monomer and (iii) a plasticizer. The higher cyanoacrylate monomer and the plasticizer are chosen from certain ones. The compositions cure to give flexible polymeric materials which are desirably also transparent.
New polymerizable adhesive compositions comprising a monomeric ester of .alpha.-cyanoacrylic acid and a difunctional monomeric cross-linking agent which is a diester of acrylic or methacrylic acid and an alcohol having at least two esterifiable hydroxyl group, are found to develop increased cohesive bond strength upon polymerization. The compositions, if desired, can contain a finely divided aggregate, preferred aggregates being alumina and quartz. In addition, the compositions can advantageously contain sodium fluoride.
A package assembly or kit can be used in conjunction with storing and dispensing adhesive materials. The package assembly can include an enclosure in which an applicator and a container may be positioned. The container contains adhesive material. The enclosure may include a base and a cover. The base preferably includes one or more cavities, with at least one applicator disposed in one of the cavities. Further, the container may be disposed in another of the cavities. The cover may be provided with a plurality of wells.
This invention relates to the process for using a fluoroalkoxyalkyl 2-cyanoacrylate in an adhesive, sealant, and/or coating composition for application to teeth, the resulting treated tooth, and compositons useful in said process.
The formulations comprise an alkyl C¿1?-C¿8? cyanoacrylate and an alkyl C¿1?-C¿8? carboxyacrylate in a proportion from 10 to 30 % by volume with respect to the cyanoacrylate. The alkyl carboxyacrylate of formula (I) is a new product which is obtained from the corresponding cyanoacrylate by hydrolysis with hydrochloric acid. The compositions are packaged in independent containers the content of which is mixed not more than one hour before its use. It can be used in surgery as alternative means for the traditional suture and is specially appropriate in ophthalmics surgery.
Carbalkoxyalkyl 2-cyanoacrylates having the formula: ##STR1## wherein R is an organic radical and R' is hydrogen or methyl polymerize rapidly in the presence of moisture and are useful as adhesives. When applied as tissue adhesives in surgical applications, such carbalkoxyalkyl 2-cyanoacrylates cause a minimum of tissue reaction and the resulting polymer is absorbable in mammalian tissue.
Disclosed are methods for draping a surgical site prior to surgery. Specifically, the methods of this invention involve the in situ formation of a cyanoacrylate polymeric drape on the skin surface of a patient peripheral to the surgical site. Surgery is then conducted at the surgical site.
