Prior to the first clinical trials of doxorubicin-loaded nanoparticles, it was necessary to prepare this formulation in such a way as to meet the requirements generally associated with parenteral administration. This paper describes the conditions under which nanoparticles should be prepared and lyophilized in order to be sterile and free of bacterial endotoxins. These nanoparticles were also subjected to a resuspension test and their size and drug adsorption capacity were found practically unchanged.
Methods and compositions for closing and sealing a wound, laceration, incision, or other percutaneous opening using an adhesive. In one preferred embodiment, the sides of the percutaneous opening are brought together in apposition and the adhesive is applied to the opening and the skin immediately adjacent thereto. Adhesives used in the methods exhibit sufficient viscosity to substantially prevent flow of the adhesive into the percutaneous opening. In a preferred embodiment, the adhesive is a sealing medium comprising an adhesive component and a microparticulate component.
A biocompatible monomer composition includes at least one monomer, which forms a medically acceptable polymer, and an effective amount of at least one heat dissipating agent sufficient to reduce exothermic polymerization temperature increase of the composition. The heat dissipating agent enhances patient comfort and prevents necrosis of living tissue normally encountered with such medical adhesives.
Propellant performance is a fucntion of propellant density. The importance of propellant density with its effect on the range and payload is exemplified by various volume limited missiles. The direction of past efforts to obtain such high density systems has been through the replacement of the oxidizer by more dense ingredients. This approach has always resulted in severe reduction in specific impulse in the more dense system. Additionally other problems were numerous.
Polycyanoacrylate foam is made by mixing together a cyanoacrylate monomer, a liquid foaming agent and a polymerisation initiator. The mixture simultaneously polymerises and foams. The foaming agent is usually an organic compound with a boiling point not higher than 100 °C, miscible with the monomer but not a solvent for the polymer. The monomer may be any 2-cyanoacrylate ester compatible with the composition.
This invention relates to compositions which polymerize to form coatings and adhesives. More particularly, the invention relates to fluorin-containing cyanoacrylate monomers which polymerize rapidly upon contact with basic materials or materials supplying hydroxyl ions, e.g. moisture in the air, to form polymers which are suitable for biological application, i.e. to bond or coat living mammalian tissues.
wherein R is hydrogen, methyl or ethyl, R' is fluorine -CF3 or -(CF2)nH, and n is an integer from 1 to 3 have been found to be useful biological adhesives which when applied as monomers to aherends rapidly polymerize, e.g., in the presence of even small amounts of moisture, to form strong bonds. The monomers polymerize to films and can be used biologically as hemostatics and tissue adhesives.
A cyanoacrylate composition comprising (i) at least one lower cyanoacrylate monomer component selected from ethyl cyanoacrylate or methoxy ethylcyanoacrylate; (ii) at least one higher cyanoacrylate monomer component than in an amount greater than 12% by weight based on the total weight of the combination of the lower cyanoacrylate monomer and the higher cyanoacrylate monomer and (iii) a plasticizer. The higher cyanoacrylate monomer and the plasticizer are chosen from certain ones. The compositions cure to give flexible polymeric materials which are desirably also transparent.
New polymerizable adhesive compositions comprising a monomeric ester of .alpha.-cyanoacrylic acid and a difunctional monomeric cross-linking agent which is a diester of acrylic or methacrylic acid and an alcohol having at least two esterifiable hydroxyl group, are found to develop increased cohesive bond strength upon polymerization. The compositions, if desired, can contain a finely divided aggregate, preferred aggregates being alumina and quartz. In addition, the compositions can advantageously contain sodium fluoride.
A package assembly or kit can be used in conjunction with storing and dispensing adhesive materials. The package assembly can include an enclosure in which an applicator and a container may be positioned. The container contains adhesive material. The enclosure may include a base and a cover. The base preferably includes one or more cavities, with at least one applicator disposed in one of the cavities. Further, the container may be disposed in another of the cavities. The cover may be provided with a plurality of wells.
