The formulations comprise an alkyl C¿1?-C¿8? cyanoacrylate and an alkyl C¿1?-C¿8? carboxyacrylate in a proportion from 10 to 30 % by volume with respect to the cyanoacrylate. The alkyl carboxyacrylate of formula (I) is a new product which is obtained from the corresponding cyanoacrylate by hydrolysis with hydrochloric acid. The compositions are packaged in independent containers the content of which is mixed not more than one hour before its use. It can be used in surgery as alternative means for the traditional suture and is specially appropriate in ophthalmics surgery.

Carbalkoxyalkyl 2-cyanoacrylates having the formula: ##STR1## wherein R is an organic radical and R' is hydrogen or methyl polymerize rapidly in the presence of moisture and are useful as adhesives. When applied as tissue adhesives in surgical applications, such carbalkoxyalkyl 2-cyanoacrylates cause a minimum of tissue reaction and the resulting polymer is absorbable in mammalian tissue.

Disclosed are methods for draping a surgical site prior to surgery. Specifically, the methods of this invention involve the in situ formation of a cyanoacrylate polymeric drape on the skin surface of a patient peripheral to the surgical site. Surgery is then conducted at the surgical site.

This invention relates to sterilized cyanoacrylate adhesive compositions with x-ray imagining capabilities, methods of making such compositions, and methods of using such compositions.

A new step in the condensation of formaldehyde and esters of 2-cyanoacetic acid to produce 2-cyanoacrylate esters which consists essentially of catalyzing the reaction by means of a mixture of an acid and the salt of a primary or secondary amine with the same stronger acid. To be effective, the catalytic mixture should have a pH value of 5 or less when exact amounts of its components are dissolved in 25 ml. of water. If the catalytic mixture is to include an acid which is not readily soluble in water (e.g. organic acids), then the pH is measured in 25 ml.

A new adhesive method using an adhesive composition including cyanoacrylate adhesive and a stabilizing agent to join together portions of a substrate, particularly useful in suturing and similar medical procedures, is disclosed.

Odontoblast-like cells derived from human tooth pulps were maintained in expiant culture and grown either on glass coverslips only (used as control) or on glass coverslips coated with cyanoacrylate films. Ultrastructural and cyto-morphometric evidence showed that cells exposed to cyanoacrylate, in contrast to controls, display a significant decrease of rough endoplasmic reticulum and mitochondria. In addition, immunofluorescent staining and radioimmunoassays for type-I collagen suggested disturbances in production for the exposed cells.

The present invention provides a surgical fastener (1) made of a bioabsorbable elastomeric material for the repair of tissues. The fastener may be elongated, thereby creating a compression force across or within the tissue being repaired. The present invention also includes embodiements drawn to methods of using the surgical fastener, such as applying the surgical fastener to a ruptured meniscus or using the surgical fastener to attach a fibrous implant or tissue transplant on or in a living tissue, and an apparatus for installing the fastener. 

A polymerizable monomer adhesive composition includes a 1,1-disubstituted ethylene monomer and at least one slip additive, where the slip additive causes a polymer film formed from the monomer to have a lower coefficient of friction than in an absence of the slip additive. The slip additive can be selected from, inter alia, fluorinated monomers or polymers, fluorinated additives, siloxane-containing monomers or polymers, siloxane-containing additives, fluorinated siloxanes, and long chain fatty acid esters.