Technical documentation

Alkyl cyanoacrylate instant adhesives are widely used because of their fast cure speed and versatility on a large number of substrates. Recent performance improvements, such as increased thermal resistance, resulted from the addition of latent acids and polymers, which do not copolymerize with the adhesive monomer, to the adhesive formulations. However, use of these additives can increase fixture time or reduce the final adhesive strength.

Ocular tolerance to cyanoacrylate tissue adhesives was evaluated in rabbits. In the experimental studies, tissue adhesives were implanted intralamellarly, subconjunctivally, and in the anterior chamber. The eyes were examined clinically and histologically at different time intervals. In the cornea and conjunctiva, the adhesive reacted as any inert material. The reaction was considerably less than that to silk or catgut. In the anterior chamber, the reaction was moderate in most cases.

The aim of the study was to compare suture, clip and clip combined with topical N-butyl cyanoacrylate in an experimental model of gastric perforation. Sixty Wistar-Albino rats were divided into three groups. Midline laparotomy was performed and a 4 mm puncture was done on the anterior surface of the stomach. Closure was performed by sutures in the first group, clip in the second group, and clip with topical cyanoacrylate in the third group. Ten rats underwent a re-laparotomy on the 3rd and 7th days, respectively.

Cyanoacrylates (CAs) were not widely adopted for medical use until recently because of lingering concerns regarding the initial tissue toxicities of the short-chain CAs. The medium-chain CAs, primarily butyl-cyanoacrylate, have been widely used in Europe and Canada for several decades and have gone a long way in dispelling any lingering concerns about tissue toxicity. The newer, longer chain CA,octyl-2-cyanoacrylate (2-OCA), now has been approved for multiple uses in the United States and has achieved widespread acceptance by the medical and lay communities.