English

Bioabsorbable cyanoacrylate-based tissue adhesives containing bioabsorbable copolymers are disclosed. The copolymers are preferably derived from .epsilon.-caprolactone, lactide and glycolide monomers or from butyl 2-cyanoacrylate, glycolide, lactide, .epsilon.-caprolactone monomers. The adhesives are characterized by increased biodegradability, increased viscosity and increased flexibility. The adhesives are useful for wound and incision closure, and for medical devices, including implants.

This invention addresses absorbable cyanoacrylate-based tissue adhesive compositions based primarily on an alkoxy cyanoacrylate combined with one or more alkyl cyanoacrylate(s), a stabilizer against premature anionic polymerization, and/or an absorbable polymeric modifier with improved, and preferably, functional properties for use, primarily, for internal wound repair applications.

A brief historical review of four series of commercially available block polymer surface-active agents—the PLURONICR, TETRONICR, PLURADOTR, and PLURONICR R polyols—is presented. A comparison is made of the physical properties within each series, in the form of trend lines. These parameters encompass solubility, rate of solubility, wetting, foaming, defoaming, emulsification, thickening, cleansing, and toxicity.

Disclosed are cyanoacrylate compositions comprising a compatible antimicrobial agent and, in particular, a compatible iodine containing antimicrobial agent. These compositions provide for in situ formation of an antimicrobial polymeric cyanoacrylate film of mammalian skin.

This invention relates to stabilized adhesives, to which silyl esters are added for stabilization.

This invention relates to an improved for preparing a dry powdered adduct of iodine and polymeric 1-vinyl-2-pyrrolidone (hereinafter called polyvinylpyrrolidone) whereby a stable composition is formed which is readily available and germicidally and bactericidally active form which is essentially non-toxic to warm-blooded animals.

Povidone Iodine or polyvinyl pyrrolidone-iodine, commonly abbreviated as PVP-I was discovered by American scientists H. A. Shelanski and M. V. Shelanski. PVP- I was introduced to the pharmaceutical market as an antiseptic agent in the 1950’s and is found to be more effective than other iodine formulations and was less toxic

This invention relates to the preparation of an adduct of iodine and polymeric 1-vinyl-2-pyrrolidone (hereinafter referred to as polyvinylpyrrolidone) whereby there is fomred a composition which is readily soluble in water to form a stable solution and which provides iodine in readily available germicidally and bactericidally active form which is essentially non-toxic to warm-blooded animals.

This invention relates to a process of stabilizing a dry powered adduct of iodine and polymeric 1-vinyl-2-pyrrolidone (hereinafter referred to as polyvinyl pyrrolidone) whereby a stable composition is obtained which when dissolved in water will not change its pH and maintain a constant available iodine content.