Many synthetic materials are being used in order to reduce the frequency of prolonged air leak (PAL) in thoracic surgical practice. This study presents our experience with the topical application of acrylate co-monomer (Glubran-2) as a synthetic tissue adhesive in an attempt to decrease troublesome postoperative air leaks in patients undergoing resection for non-small cell lung carcinoma. Of the 112 patients who had undergone resection for lung carcinoma, 69 patients having lobectomy or bilobectomy were included in this study.
Octyl-2-cyanoacrylate is a long carbon chain cyanoacrylate derivative that is stronger and more pliable than its shorter chain derivatives. One hundred and eleven patients underwent elective surgical procedures by the same surgeon using either octyl-2-cyanoacrylate or sutures for skin closure at the University of Illinois at Chicago. Most patients underwent excision of benign skin lesions with a mean wound size of 112 mm3. Patients were randomized into either control (vertical mattress suture closure) or test groups (closure with octyl-2-cyanoacrylate).
Although small lacerations of the myocardium may be repaired easily using conventional methods, larger tears or ruptures, especially if they occur in infarcted myocardial tissue, may create formidable technical challenges. Described is a method for applying sutureless pericardial patches for control of hemorrhage.
METHODS:
A sutureless pericardial patch was glued to the myocardium with commercially available household cyanoacrylate (Krazy Glue) in seven patients.
The aim of this study was to compare the physical properties (tensile strength and burst pressure) of TissuePatch3 with commercially available comparator products, namely TisseelTM(Baxter), TachoSil®(Nycomed) and PleuraSealTM(Covidien). The tensile strength of TissuePatch3 was statistically greater than that of TachoSil (t- test, p=0.01), under both wet and dry conditions. The tensile strength of PleuraSeal and Tisseel could not be assessed, due to problems during sample preparation. The mean burst pressure of Tisseel was significantly lower than that of TissuePatch3 (t- test, p=0.01).
A medical and surgical adhesive compostion is described which provides an increased elasticity of the adhesive film and which is free of side effects, comprising 2-ehtyl cyanoacrylate, butyl acrylate and 3-methacryloxy sulfolane.
Simultaneous cellular resistance to multiple lipophilic drugs represents a major problem in cancer chemotherapy. This drug resistance may appear clinically either as a lack of tumor size reduction or as the occurrence of clinical relapse after an initial positive response to antitumor treatment. The resistance mechanism can have different origins either directly linked to specific mechanisms developed by the tumor tissue or connected to the more general problem of distribution of a drug towards its targeted tissue.
This review considers the use of poly(alkylcyanoacrylates) (PACAs) as biomedical materials. We first present the different aspects of the polymerization of alkylcyanoacrylate monomers and briefly discuss their applications as skin adhesives, surgical glues and embolitic materials. An extensive review of the developments and applications of PACAs as nanoparticles for the delivery of drugs is then given.
