Devices and methods for Applying a Mixture of two or more Liquid Components to Form a Biomaterial

US006206905B1 (12) United States Patent (10) Patent N0.: US 6,206,905 B1 Holm et al. (45) Date of Patent: Mar. 27, 2001 (54) DEVICES AND METHODS FOR APPLYING A (56) References Cited MIXTURE OF TWO OR MORE LIQUID COMPONENTS TO FORM A BIOMATERIAL US PATENT DOCUMENTS 5,887,755 * 3/1999 Hood, 111 ........................... .. 222/135 (75) Inventors: Niels Erik Holm, Birkergzsd; Steven .1 ~ d b ~ Linnebjerg, Skaevinge, both of (DK); Cue y exammer Richard Cornwell, Deeside (GB) Primary Examiner—Michael Buiz Assistant Examiner—(Vikki) Hoa B. Trinh (73) Agsjgneeg Bristo]-Myers Squibb Company, New (74) Attorney, Agent, or Firm—Theodore R. Furman, Jr.; York, NY (US) John M. Kilcoyne; Stuart E. Krieger 57 ABSTRACT ( * ) Notice: Subject to any disclaimer, the term of this ( ) patent iS €Xt€I1d€d Of adjusted under 35 Novel methods and devices which provide enhanced mixing U-S-C 154(b) by 0 days. and application of two liquid components to form a bioma- terial with minimized aerosols is achieved using air flow (21) Appl, No; 09/358,078 rates below about 1.25 liters/minute in combination with a 22 F1 d. 1 21 1999 ratio of air flow to total liquid flow of from about 150:1 up ( ) 1 e ‘ J“ ' 3 to about 1500:1. Preferably the air flow is below about 1 liter/minute and the ratio of air flow to total liquid flow is from about 200:1 to about 120021. The parameters are ideally suited for the spray application of components which Related U.S. Application Data (62) Division of application No. 08/970,291, filed on Nov. 14, 1997. form a surgical sealant, e.g., a fibrin sealant. Also a part of (60) Provisional application No. 60/030,942, filed on Nov. 15, the Pre5‘fnt inVemi0n We novel application meth0d§ R.” 1996. biomaterial, e.g., surgical sealant, components at liquid (51) Int. Cl.7 ................................................... .. A61B 17/08 fl°WS b‘°’1°W 1'9 ml/”““‘”°’ “ml methods “‘V°1““g ‘he mixing of such components on the exit surface of a spray tip or nozzle, novel spray tips and biomaterial applicators and methods for making such applicators. (52) U.S. Cl. ............................................................ .. 606/214 (58) Field of Search ................................... .. 606/213, 214; 604/68-72, 82, 57, 191, 272, 225; 222/137, 135, 136 7 Claims, 7 Drawing Sheets U.S. Patent Mar. 27, 2001 Sheet 1 of 7 US 6,206,905 B1 U.S. Patent Mar. 27, 2001 Sheet 2 of 7 US 6,206,905 B1 FIG. 2 m .0_n_ U.S. Patent Mar. 27, 2001 Sheet 3 of 7 US 6,206,905 B1 US 6,206,905 B1 ¢ .0_n_ U.S. Patent Mar. 27, 2001 Sheet 5 of 7 US 6,206,905 B1 m .0_n_ U.S. Patent Mar. 27, 2001 Sheet 6 of 7 US 6,206,905 B1 9 mm .o_.._ Tl xm.n §. Ii nu