degradation

Polycyanoacrylates were found to be inherently unstable. Even in the absence of a deliberately added strong base, their molecular weights decreased drastically on standing in solution in accord with observations by Ryan and McCann (Makromol Chem Rapid Commun 1996, 17, 217). The initial high molecular weight polymer disappeared over the course of a few hours in solution and was replaced by a much lower molecular weight material.

This review considers the use of poly(alkylcyanoacrylates) (PACAs) as biomedical materials. We first present the different aspects of the polymerization of alkylcyanoacrylate monomers and briefly discuss their applications as skin adhesives, surgical glues and embolitic materials. An extensive review of the developments and applications of PACAs as nanoparticles for the delivery of drugs is then given.

This paper reviews biodegradable synthetic polymers fo- cusing on their potential in tissue engineering applications. The major classes of polymers are briefly discussed with regard to synthesis, properties and biodegradability, and known degradation modes and products are indicated based on studies reported in the literature. A vast major- ity of biodegradable polymers studied belongs to the poly- ester family, which includes polyglycolides and polylactides.