The synthesis of t-butyldimethylsilyl cyanoacetate and the reactions of its anion with acyl donors are described. The reagent was found to be the method of choice for the syntheses of α-cyano ketone substrate analogues for carboxypeptidase A. These compounds have been shown to be potent mechanism-based inactivators for the enzyme.
An artificial fingernail material is disclosed. It contains base-treated bone powder of a particular particle size in a curable adhesive. A process for applying this material to the nail by applying an adhesive, adding bone powder and repeating as needed is disclosed as is the process for preparing the particular bone powder.
Nail polish is disclosed, based upon a film-former, a resin component and a solvent system, containing as film-former and/or resin component an O-benzyl-N-hydroxyalkyl chitosan of the formula (I) The polish film obtained with the nail polish posesses a high luster, outstanding adhesion, as well as an increased hardness compared to nail polishes based upon nitro-cellulose, with even more sufficient elasticity. Also includd in the present invention are the new O-benzyl-N-hydroalkyl-chitosans of formula (I).
A curable composition, in which powder of an organic or inorganic compound is added to and dispersed in a 2-cyanoacrylate and an acidic substance and a basic substance are contained as the stabilizer. In the curable composition of the invention, powder of organic or inorganic compound can be stably dispersed into the composition by the combined use of the acidic substance and the basic substance, thereby providing desired properties with ease while giving excellent storage stability and maintaing the instantaneous curing property of the composition.
Twenty-six alkyl, alkenyl, cycloalkyl, and substituted alkyl 2-cyanoacrylates were synthesized in the pure state. The purity was determined by gas-liquid chromatography, and a correlation between the log retention time and the number of carbons in the compounds within the homologous series was deduced. Their physical properties such as parachor and molar refraction were determined and the data were fitted to a linear relation to the number of carbons present in the ester within a homologous series of cyanoacrylates.
A photometric assay was developed to study the surface erosion of polymeric nanoparticles. The hydrolytic degradation of polyalkylcyanoacrylate particles was studied in different environments (NaOH, buffer, cell culture medium and serum). The influence of particle modification on the degradation rate was assessed. Particularly, the effect of polymer coating for particle targeting and fluorescence labelling was investigated. From the absorption data, a t 50% and t 100% can be calculated for fast degrading particles and obtained by an extrapolation in case of a slow degradation process.
An emulsion containing a substantially water resistant film-forming copolymer phase and iodine is claimed. The polymer-in-water emulsion forms a film that is a substantially fluid resistant, low tack, flexible film which adheres to skin and releases iodine to skin. The addition of iodate to emulsions having such a film-forming copolymer phase and iodine further enhances stability of the emulsion.
