Glycolates

A series of alkyl 2-cyanoacryloyl glycolate tissue adhesives were synthesized and characterized by NMR. Physical properties and bond strengths are presented. Within the series, bond strength decreased with increasing molecular weight. Corresponding polymers were evaluated by in vitro and in vivo techniques for biocompatibility. In general, in vitro biocompatibility increased with molecular weight.

a-cyanoacrylate compounds expressed by the following general formula: wherein R' desianates- and R2 designates alkyl groups, alkenyl groups or alkynyl groups of C1 to C4. These compounds are preferably synthesized by the reaction of the compounds expressed by the following general formula: wherein R' and R2 are same as the above described, with formaldehyde products and then the depolymerization of the resulting dehydrating condensation polymers. These compounds are effectively used as fast-setting adhesives.