Nowadays, solvent-free, one-part cyanoacrylate adhesive is widely used in medicine and dentistry. According to a literature survey done by the authors, there are few papers concentrated on the role of nano-sized particles on the thermal behavior of cyanoacrylate glue. Thus the main goal of the current research focused on clarifying the role of nano-sized SiO2 on the thermal behavior of cyanoacrylate. Thermal behavior of all materials including cyanoacrylate and its nanocomposites was studied by using Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) methods.